Evolution is rendering our medicines against many infections useless threatening to bring us back to the pre-antibiotic era. In many cases resistance to a particular antibiotic did not evolve within the resistant human pathogen, but rather was acquired by lateral gene transfer from other resistant bacteria. These resistant donor bacteria need not be pathogenic, yet they contribute to the evolution of antibiotic resistance in human pathogens by serving as an accessible reservoir of resistance genes. We are using a variety of culture-dependent and culture-independent methods to characterize how these reservoirs are interacting, with the ultimate goal of creating quantitative models for how antibiotic resistance genes arise in human pathogens. We also study the adaptive mechanisms of drug resistance using a combination of laboratory evolution and sampling of clinical isolates, with the goal of developing novel treatment strategies for countering resistance development.
Increasing concerns related to climate change caused by our reliance on fossil fuels for many processes in our society prompt the need to look for alternatives. Biological systems can be engineered to perform conversions of renewable input substrates to value added products using much less energy than conventional methods. We use a variety of metagenomic and culture based techniques for harnessing biological diversity useful for generation of biofuels and other value chemicals.
An overwhelming number of important processes ranging from dietary processing in humans to global carbon cycling are driven by microbial communities. The community structure is complex and the underlying principles governing the establishment and evolution of these communities are poorly understood. We are studying a combination of synthetic engineered communities and natural communities to further our understanding of these fundamental principles.
Lejla Imamovic introduces the principle of collateral sensitivity cycling.
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Talented and motivated applicants interested in joining our lab as a post doctoral fellow or a PhD-student should send their application, including CV and references to:
While funding is available for some positions, we encourage candidates to apply for their own funding (salary).
The Sommer lab has a wide range of projects available for master students (speciale) and undergraduates. If you are interested in our research and would like to do a project in the lab please contact Morten Sommer for further information. Please include CV and your grades from your studies so far.
Novo Nordisk Foundation Center for Biosustainability
Kogle Alle 6
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